| Autor: |
KAGESHITA, TOSHIRO, CHEN, ZHI JIAN, KIM, JIN-WOO, KUSAMA, MIKIHIRO, KEKISH, ULANA MARIA, TRUJILLO, TRACY, TEMPONI, MASSIMO, MITTELMAN, ABRAHAM, FERRONE, SOLDANO |
| Zdroj: |
Pigment Cell Research; 1988, Vol. 1 Issue s1, p185-191, 7p |
| Abstrakt: |
Following a discussion of the rationale underlying the selection of human melanoma to test the usefulness of anti-idiotypic monoclonal antibodies in the therapy of solid tumors, the development of the anti-idiotypic monoclonal antibody MoAb) MF11-30 is described. This antibody recognizes a private idiotope within the antigen-combining site of the immunizing antihuman high molecular weight melanoma-associated antigen MoAb 225.28. The results of a phase I clinical trial with the MoAb MF11-30 in patients with advanced melanoma are described. The lack of toxic effects and the minor responses in six patients suggest that these studies should be extended to a larger number of patients with an emphasis on the analysis of the mechanisms underlying the clinical response. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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