| Autor: |
YOONG, YAN, STORY, MARGOT E., ISHAC, E. J., PENNEFATHER, JOCELYN N., HANDBERG, GWYNNETH M. |
| Zdroj: |
Journal of Autonomic Pharmacology; 1982, Vol. 2 Issue 3, p161-168, 8p |
| Abstrakt: |
1 The effect of hypothyroidism, induced by methimazole, upon the respone of the isolated portal vein of the rat to adrenoreceptor agonists and antagonists, to angiotensin II and to papaverine has been investigated. 2 The positions and maxima of log dose-response curves, to the vasoconstrictor agonists, noradrenaline and angiotensin II, and to the vasodilator agonists isoprenaline and papaverine, were unaffected by methimazole treatment. 3 The α-adrenoreceptor antagonist phentolamine competitively inhibited the effects of noradrenaline to a similar extent in preparations from control and hypothyroid animals. The competitive antagonism of isoprenaline by the β-adrenoreceptor antagonist propranolol was similarly unaffected by hypothyroidism. 4 These results taken together indicate that hypothyroidism is without significant effect upon either the properties of postjunctional α- β-adrenoreceptors in the rat portal vein, or upon the reactivity of this blood vessel to the vasoactive agonists studied. [ABSTRACT FROM AUTHOR] |
| Databáze: |
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