| Autor: |
Jebbink, MC, Jansen, JB, Masclee, AA, Lamers, CB |
| Zdroj: |
British Journal of Clinical Pharmacology; 1990, Vol. 29 Issue 6, p770-773, 4p |
| Abstrakt: |
Saline or loxiglumide (2.5 mg kg-1 in 10 min, followed by 5 mg kg-1 h-1 for 200 min) was administered intravenously in random order to six healthy subjects. After 60 min cholecystokinin (CCK-33) was infused (0.5 i.d.u. kg-1 h-1 for 1 h then 1.0 i.d.u. kg-1 h-1 for 1 h). Loxiglumide did not change basal levels of CCK and did not augment plasma CCK-immunoreactivity during CCK-33 infusion. After cessation of the CCK-infusion, plasma CCK concentrations decreased rapidly to basal values within 12 min, and the elimination half-life during loxiglumide infusion (4.8 +/− 0.8 min) was not significantly different from that during saline infusion (4.2 +/− 1.0 min). These results suggest that loxiglumide does not interfere with the distribution and metabolism of CCK. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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