| Autor: |
Feitsma, KG, Postma, DS, Koeter, GH, Nossent, GD, Brenth, BF, Zeeuw, RA |
| Zdroj: |
British Journal of Clinical Pharmacology; 1988, Vol. 25 Issue 6, p683-687, 5p |
| Abstrakt: |
1. Racemic oxyphenonium bromide, its enantiomers and placebo were inhaled by eight adult patients with chronic airflow obstruction, in a four-way double-blind cross-over study. 2. Forced expiratory volume in one second (FEV1) and slow inspiratory vital capacity (VC) were measured during the first 6 h after inhalation. 3. (+)-Oxyphenonium was found to be the active enantiomer (eutomer), providing better bronchodilation than (+/-)-oxyphenonium. 4. The distomer, (−)− oxyphenonium, showed only a slight effect on FEV1 and VC as compared with placebo. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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