| Autor: |
Weber, RR, McCoy, CE, Ziemniak, JA, Frederickson, ED, Goldberg, LI, Murphy, MB |
| Zdroj: |
British Journal of Clinical Pharmacology; 1988, Vol. 25 Issue 1, p17-21, 5p |
| Abstrakt: |
1 The pharmacokinetic properties of intravenous fenoldopam, a selective dopamine1-receptor agonist, were studied in 10 patients with essential hypertension. 2 Reduction in blood pressure was linearly related to the log fenoldopam plasma concentration (r = 0.69) and the log fenoldopam infusion rate (r = 0.71). 3 The mean elimination half-life (+/- s. e. mean) was 9.8 +/- 1.0 min. The total body clearance was 30.3 +/- 2.3 ml kg-1 min-1 and the volume of distribution was 582 +/- 62 ml kg-1. 4 The rapid onset of action, short elimination half-life, linear dose- response relationship, and ease of administration suggest that fenoldopam may have a role where parenteral treatment of hypertension is required. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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