| Autor: |
Darragh, A., Lambe, R., Kenny, M., Brick, I., Taaffe, W., O'Boyle, C. |
| Zdroj: |
British Journal of Clinical Pharmacology; 1982, Vol. 14 Issue 5, p677-682, 6p |
| Abstrakt: |
1 In a double-blind, placebo controlled study, the efficacy of Ro 15- 1788, a new benzodiazepine antagonist, in blocking the cognitive, psychomotor and subjective effects of diazepam, was investigated in a group of six healthy male volunteers. 2 The central effects of orally administered diazepam (40 mg) were most pronounced 1 h after dosing and persisted for 9 h with decreasing severity. 3 Concurrent oral administration of Ro 15-1788 (200 mg) completely prevented the impairment in cognitive and psychomotor function observed after diazepam alone. 4 The duration of action of Ro 15-1788 was shorter than that of diazepam. 5 Plasma diazepam levels after administration of the diazepam/antagonist combination were very similar to those observed following diazepam alone. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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Plný text