Tiaramide-a new oral drug for the treatment of asthma.

Autor: Berkin, KE, Kerr, JW
Zdroj: British Journal of Clinical Pharmacology; 1982, Vol. 14 Issue 4, p505-508, 4p
Abstrakt: 1 TIaramide, an anti-inflammatory drug, inhibits the action of mediators released from mast cells and has direct smooth muscle relaxant properties. It may therefore have a beneficial effect in asthma. 2 A double-blind crossover trial comparing the bronchodilator activity of tiaramide and placebo over 16 days was undertaken in 13 patients with asthma. 3 Peak expiratory flow rate (PEFR) was recorded on three separate occasions every day and frequency of salbutamol aerosol usage was noted on a diary card. 4 During treatment with tiaramide the mean mid-morning PEFR (362 1/min) was higher than mean PEFR on placebo (328) (P less than 0.001) as was the evening PEFR (378) compared with placebo (388) (P less than 0.001). 5 There was a significant reduction in daily use of the salbutamol inhaler whilst on tiaramide (1.8) compared with placebo (2.3) (P less than 0.05). 6. Tiaramide may be a useful addition to existing prophylactic treatment for asthma. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index
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