Atenolol in the treatment of essential hypertension during pregnancy.

Autor: Rubin, PC, Butters, L, Low, RA, Reid, JL
Zdroj: British Journal of Clinical Pharmacology; 1982, Vol. 14 Issue 2, p279-281, 3p
Abstrakt: Atenolol has been studied prospectively in the management of ten patients with essential hypertension during pregnancy. Median supine BP fell significantly from 156/98 mmHg before treatment to 128/82 mmHg at term. Atenolol did not suppress cardiotocographic signs of foetal distress. Although there was one intrauterine death, the remaining nine babies had a median Apgar score at birth of 9 and a median weight which was 82% of the gestational mean. There were no cases of neonatal bradycardia or respiratory depression and the only case of hypoglycaemia was in a dysmature baby. These findings justify a formal study of beta-adrenoceptor blocker therapy in hypertensive diseases of pregnancy. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index