Effect of pirprofen on glibenclamide kinetics and response.

Autor: Morrison, PJ, Rogers, HJ, Spector, RG, Bradbrook, ID, John, VA
Zdroj: British Journal of Clinical Pharmacology; 1982, Vol. 14 Issue 1, p123-126, 4p
Abstrakt: Pirprofen (a new non-steroidal anti-inflammatory agent), 200 mg 8 hourly, or placebo was administered orally to eight normal volunteers to investigate its effect on the pharmacokinetics and glucose and insulin responses after 1 mg i.v. glibenclamide. No significant changes were produced in these measures and in vitro studies showed no displacement of glibenclamide by pirprofen from plasma protein binding. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index