| Autor: |
Austin, KL, Stapleton, JV, Mather, LE |
| Zdroj: |
British Journal of Clinical Pharmacology; 1981, Vol. 11 Issue 1, p25-30, 6p |
| Abstrakt: |
1 Pethidine pharmacokinetics in ten female patients during continuous i.v. infusion for 32 h post-surgery have been determined. 2 The blood clearance of pethidine (mean +/− 2.d.) measured directly was 599 +/− 135 ml/min and is in marked contrast to some reported values. 3 Other model-dependent pharmacokinetic parameters were consistent with previously reported values. 4 Pethidine and indocyanine green clearance were correlated but the correlation was mediated through body weight. 5 Pethidine clearance and steady state concentration were predictable retrospectively from linear multivariable equations involving simple physical characteristics of the patient. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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