| Autor: |
Wilkinson, R, Stevens, IM, Pickering, M, Robson, V, Hawkins, T, Kerr, DN, Harry, JD |
| Zdroj: |
British Journal of Clinical Pharmacology; 1980, Vol. 10 Issue 1, p51-59, 9p |
| Abstrakt: |
1 The effects of propranolol and atenolol given in random order in a cross-over study to fifteen patients with essential hypertension have been studied. 2 Both drugs were effective in lowering blood pressure and side effects were not markedly different. 3 There was no change in exchangeable sodium or potassium or in total body potassium during treatment with either drug. 4 Ambulant plasma renin activity was reduced by both drugs but the fall in blood pressure was not related to initial plasma renin. 5 Despite equal mean reduction in blood pressure with the two drugs, creatinine clearance fell significantly only during treatment with propranolol. 6 These observations suggest that intra- renal beta 2-adrenoceptors may be of importance in the regulation of renal function. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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