| Autor: |
Desai, NK, Sheth, UK, Mucklow, JC, Fraser, HS, Bulpitt, CJ, Jones, SW, Dollery, CT |
| Zdroj: |
British Journal of Clinical Pharmacology; 1980, Vol. 9 Issue 4, p387-394, 8p |
| Abstrakt: |
1 Antipyrine clearance has been measured using saliva samples in 50 Maharashtrans from a village to the north of Bombay. 2 All subjects were very lean and were also anaemic probably as a result of hookworm infestation. 3 Antipyrine clearance was 36% faster than in White Londoners studied previously and more than twice as fast as in Asian immigrants living in London. 4 Clearance was 25% faster in men than in women but volume of distribution was also greater in men and mean half- lives did not differ significantly between the sexes. 5 There was a negative correlation between antipyrine clearance and haemoglobin concentration. 6 The study has identified geographic differences in antipyrine metabolism which could be clinically important. The role of anaemia merits further study. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
|
Plný text