| Abstrakt: |
Δ1 - trans-tetrahydrocannabinol (Δ1-THC; 10 mg) or a placebo was given orally on 7 days to two groups of six patients on a cross-over pattern with 7 days rest between., The patients were hospitalized, suffering from inoperable bronchogenic carcinoma, subjected to radiation therapy, and anxious., Self-rating mood scales were filled in before, and 2 and 6 h after ingestion on the first and seventh day of medication., Records of sleep, pain, general well-being, temperature, cardiovascular and gastrointestinal parameters were kept., Δ1-THC caused drowsiness and improved night sleep, reduced pain, increased fatigue and confusion and reduced elation and vigour; it caused slight tachycardia and hypotension as also did placebo., The effects of Δ1-THC were stronger after 2 h than 6 h and no tolerance had developed at 7 days., The management of stressful patients was considered to have been improved by the drug. [ABSTRACT FROM AUTHOR] |
Plný text