| Autor: |
Hillan, Kenneth J., Hagler, Kelly E., MacSween, Roderick N. M., Ryan, Anne M., Renz, Mark E., Chiu, Henry H., Ferrier, Rod K., Bird, George L., Dhillon, Amar P., Ferrell, Linda D., Fong, Sherman |
| Zdroj: |
Liver; 1999, Vol. 19 Issue 6, p509-518, 10p |
| Abstrakt: |
Aims/Background: The integrin α4β7 and mucosal addressin cell adhesion molecule-1 (MAdCAM-1) are involved in normal recirculation of lymphocytes between the blood and the tissues of the gastrointestinal tract. In this study we have examined the expression of MAdCAM-1 in human liver. Methods: MAdCAM-1 expression was determined in archival human liver tissues by immunohistochemistry. Results: While MAdCAM-1 was not detected in normal fetal or adult human liver, expression was observed in association with portal tract inflammation in a variety of liver diseases. Detailed analysis of liver biopsies from patients with hepatitis C showed a positive correlation between the portal/periportal component of the histological activity index (HAI) grade and the presence or absence of MAdCAM-1 expression. Conclusion: MAdCAM-1 expression may be important in the recruitment of lymphocytes to the liver during inflammation. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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