| Autor: |
Lay, Chii-Shyan, Tsai, Yang-Te, Kong, Chi-Woon, Lee, Fa-Yauh, Lee, Shou-Dong, Lo, Kwang-Juei, Chiang, Benjamin N., Chen, Kuang-Y |
| Zdroj: |
Liver; 1987, Vol. 7 Issue 4, p223-227, 5p |
| Abstrakt: |
ABSTRACT- The acute effects of Nifedipine on hepatic venous pressure gradient (HVPG) and estimated hepatic blood flow (EHBF) were investigated in six patients with HBsAg-positive cirrhosis and portal hypertension by simultaneous hepatic venous catheterization. The mean arterial pressure significantly decreased by 18% at 1 h after sublingual administration of 10 mg Nifedipine. Significant increases in heart rate (13%) and cardiac output (20%) were also demonstrated in our patients 1 h after administration of Nifedipine. However, there were no significant changes in HVPG and EHBF after Nifedipine. We conclude that in patients with HBsAg-positive cirrhosis who receive Nifedipine, EHBF is maintained despite a substantial change in systemic hemodynamics, and that Nifedipine is not effective in acutely reducing HVPG. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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