| Autor: |
Pamperl, H., Gradner, W., Fridrich, L., Pointner, H., Denk, H. |
| Zdroj: |
Liver; 1984, Vol. 4 Issue 5, p294-300, 7p |
| Abstrakt: |
ABSTRACT- In 35 patients on long-term anticonvulsant treatment (7-35 years, x̄ = 19.6 years), various liver enzymes were measured. In 32 cases (91.4%), elevated levels of serum-gamma-glutamyl-transpeptidase (GGT) were found. Liver biopsy was performed in five of 13 patients with GGT levels of >60 U/1 (75-257, x̄ = 123 U/1). Light microscopy showed a minimal steatosis and fine granular appearance of hepatocytes in two cases, and a slight portal fibrosis in one case. Two cases showed an unremarkable histology. Electron microscopy revealed signs of enzyme induction as overall swelling of the smooth endoplasmic reticulum and additionally a dilatation of the rough endoplasmic reticulum in all five specimens. No signs of liver damage or disturbance of liver function could be observed. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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