| Autor: |
Giordano, Giuseppe, Shyam, Krishnamurthy, Sartorelli, Alan C., McMurray, Walter J. |
| Zdroj: |
Organic Mass Spectrometry; 1992, Vol. 27 Issue 5, p633-635, 3p |
| Abstrakt: |
Several 1,2,2-tris(sulfonyl)hydrazines, conceived as prodrugs of 1,2-bis(sulfonyl)hydrazines and synthesized as potential antineoplastic and trypanocidal drugs, were analyzed by mass Spectrometry as part of the confirmation of the structure of these compounds. Since these compounds showed activity against several transplanted animal tumors, an understanding of the mass spectral behavior of these agents is important to gain information should clinical trials and metabolic studies be undertaken. In all spectra, protonated molecular ions were observed. Collision activation resulted in considerable fragmentation in the fast atom bombardment spectra. Rearrangement ions formed by elimination of substituted diimides from the middle of the molecule were observed. Other rearrangements involving the alkyl substituent and sulfonyl oxygen also occurred. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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