DOSAGE EFFECTS AND INDIVIDUAL RESPONSIVITY TO METHYLPHENIDATE IN ATTENTION DEFICIT DISORDER.

Autor: Douglas, V. I., Barr, R. G., Amin, K., O'Neill, M. E., Britton, B. G.
Zdroj: Journal of Child Psychology; 1988, Vol. 29 Issue 4, p453-475, 23p
Abstrakt: Effects of three dosages of methylphenidate (0.15, 0.30 and 0.60 mg/kg) were assessed in 19 ADD-H children on a variety of cognitive, academic and behavioral measures in the laboratory and the classroom. A predominant linear pattern of improvement was found across almost all measures. A slight decrease between 0.3 and 0.6 mg/kg on one cognitive task leaves open the possibility that higher dosages reduce stimulant effectiveness or cause decrements on some kinds of 'high-level/high load' tasks. Response patterns of individual children varied considerably across measures. All children improved on at least several measures. Results were interpreted as evidence for stimulant activation of self-regulatory processes. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index