New Combination Chemotherapy Programme for Bladder Cancer.

Autor: WAXMAN, J., ABEL, P., JAMES, N., FARAH, N., O'DONOGHUE, E. P. N., MEE, D., COLBECK, R., SIKORA, K., WILLIAMS, GORDON
Zdroj: British Journal of Urology; 1989, Vol. 63 Issue 1, p68-71, 4p
Abstrakt: - Forty patients with either metastatic, post-radiotherapy recurrent, or poor prognosis locally advanced transitional cell carcinoma of the bladder were treated in a new combination chemotherapy programme with methotrexate, vinblastine, mitozantrone and JM8 (carboplatin); 33 patients were assessable for response. There were 9 complete responses (27%), 12 partial responses (36%) and 7 disease stabilisations (21%); 5 patients (15%) had progressive disease. The median duration of complete response has not been reached and is in excess of 9 months (range 4- > 18 months). This regimen was without significant toxicity and this is in contrast with M-VAC, which is thought to be currently the most effective treatment for urothelial cancer. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index