A Phase II Study of lntravesical Mitomycin C in the Treatment of Superficial Bladder Cancer.

Autor: HARRISON, G. S. M., GREEN, D. F., NEWLING, D. W. W., RICHARDS, B., ROBINSON, M. R. G., SMITH, P. H.
Zdroj: British Journal of Urology; 1983, Vol. 55 Issue 6, p676-679, 4p
Abstrakt: - Twenty-three patients with histologically prjoven superficial bladder cancer (Tis, Ta, T1) were treated with intravesical instillations of Mitomycin C at a dose of 20 mg in 20 ml of water 3 times weekly for 21 instillations. Seventeen patients (77%) showed complete disappearance of all known disease and a further 4 showed partial responses. In 8 patients toxic effects developed (thrombocytopaenia 1, chemical cystitis 2, skin rash 3, urinary tract infection 2). All resolved rapidly on stopping the treatment but were severe enough in 5 patients to prevent them from receiving a full course of treatment. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index