| Autor: |
Kautzky-Willer, Alexandra, Krssak, Martin, Winzer, Christine, Pacini, Giovanni, Tura, Andrea, Farhan, Serdar, Wagner, Oswald, Brabant, Georg, Horn, Rüdiger, Stingl, Harald, Schneider, Barbara, Waldhäusl, Werner, Roden, Michael |
| Předmět: |
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| Zdroj: |
Diabetes; Feb2003, Vol. 52 Issue 2, p244-251, 8p, 4 Charts, 4 Graphs |
| Abstrakt: |
Women with previous gestational diabetes (pGDM) are frequently insulin-resistant, which could relate to intramyocellular lipid content (IMCL). IMCL were measured with ¹H nuclear magnetic resonance spectroscopy in soleus (IMCL-S) and tibialis-anterior muscles (IMCL-T) of 39 pGDM (32 ± 2 years, waist-to-hip ratio 0.81 ± 0.01) and 22 women with normal glucose tolerance (NGT; 31 ± 1 years, 0.76 ± 0.02) at 4-6 months after delivery. Body fat mass (BFM) was assessed from bioimpedance analysis, insulin sensitivity index (S[sub I]), and glucose effectiveness (S[sub G]) from insulin-modified frequently sampled glucose tolerance tests, pGDM exhibited 45% increased BFM, 35% reduced S[sub I] and S[sub G] (P < 0.05), and 40% (P < 0.05) and 55% (P < 0.005) higher IMCL-S and IMCL-T, respectively. IMCL related to body fat (BFM P < 0.005, leptin P < 0.03), but only IMCL-T correlated (P < 0.03) with S[sub I] and glucose tolerance index independent of BMI. Insulin-resistant pGDM (n = 17) had higher IMCL-S (+66%) and IMCL-T (+86%) than NGT and insulin-sensitive pGDM (+28%). IMCL were also higher (P < 0.005, P = 0.05) in insulinsensitive pGDM requiring insulin treatment during pregnancy and inversely related to the gestational week of GDM diagnosis. Thus, IMCL-T reflects insulin sensitivity, whereas IMCL-S relates to obesity. IMCL could serve as an additional parameter of increased diabetes risk because it identifies insulin-resistant pGDM and those who were diagnosed earlier and/or required insulin during pregnancy. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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