Decreased plasma enkephalins in copper deficiency in man.

Autor: Bhaihena, Sam J., Recant, Lillian, Voyles, Nancy R., Timmers, Kim I., Reiser, Sheldon, Smith Jr., J. Cecil, Powell, Andrea S.
Předmět:
Zdroj: American Journal of Clinical Nutrition; Jan1986, Vol. 43 Issue 1, p42-46, 5p
Abstrakt: Twenty-four male subjects participated in a study in which the effect of feeding diets low in copper (1.03 mg/day) on plasma opiates was determined. The subjects were fed a low-copper diet for 11 wk with either starch or fructose as a major source of carbohydrate. Feeding low-copper diet decreased serum copper level significantly. In addition, plasma Ieu- and met-enkephalins decreased significantly while β-endorphin levels rose. On repletion with copper (3 mg/day) for 3 wk, plasma enkephalins increased while β-endorphin levels decreased to pretest values. These results suggest that feeding low copper decreases plasma enkephalins, which may reflect a copper-dependent process affecting enkephalin biosynthesis and/or release. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index