| Autor: |
Kanazirev, Branimir, Zortcheva, Rossitsa, Ikonomov, Valentin |
| Předmět: |
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| Zdroj: |
BANTAO Journal; 2012, Vol. 10 Issue 2, p69-73, 5p |
| Abstrakt: |
Introduction. End-stage renal disease (ESRD) patients are at increased risk of tissue calcification because of deranged calcium-phosphorus metabolism. We have tested the hypothesis that pericardial fibrosis (PF) and thickness (PT) correlate with cardiac valvular calcification (CVC) in ESRD patients. Methods. Echocardiography was performed in 23 ESRD patients. PT was measured in the parasternal long-axis M-mode at the site of the posterior pericardium and CVC at the sites of the aortic and mitral valves. All parameters were defined in 3 grade scores. Hemoglobin, urea, creatinine, beta-2 microglobulin, Creactive protein, calcium (Ca), phosphorus (P), CaxP product and PTH were measured. Results. Eighteen patients (78.26%) had calcium deposits on the aortic valve and 13 patients (56.52%) had mitral calcification. All-cause 2-year mortality was 34.8%-8 patients have died in the follow-up period. Virtually all patients had some degree of PT. The mean PT was 4.87±1.89 mm while normal values were considered below 2 mm (1.2±0.8). Correlations were as follows: 1) PT with aortic and mitral CVC score r=0.478 (p<0.05) with aortic valve and r= 0.484 (p<0.01) with mitral valve; 2) PT score with aortic valve score - r=0.208 and mitral valve score r=0.231; 3) PT with CaxP product and HD-duration: r=0.333 and r=- 0.401, and PT-score: r=0.401 (p<0.05) and r=0.053 respectively; 4) PT and PT score with all-cause 2-year mortality: r=0.270 and 0.407 (p<0.05), respectively. Pericardial Score combined with Aortic Valve Score and Mitral Valve Score had r coefficient 0.386 (p<0.01) with 2-year allcause mortality. Conclusions. The associations between pericardial thickness and valvular calcifications and all-cause mortality show weak-to-moderate correlations, but might well be yet another site for risk stratification of calcium burden deposition and prognosis in patients on HD. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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