Neolignans from the Fruits of Magnolia obovata and Their Inhibition Effect on NO Production in LPS-Induced RAW 264.7 Cells.
| Autor: | Kyeong-Hwa Seo, Dae-Young Lee, Dong-Sung Lee, Ji-Hae Park, Rak-Hun Jeong, Ye-Jin Jung, Shrestha, Sabina, In-Sik Chung, Geum-Soog Kim, Youn-Chul Kim, Nam-In Baek |
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| Předmět: |
CHROMATOGRAPHIC analysis
ANALYSIS of variance ANIMAL experimentation CELL culture CELL physiology LIGNANS MASS spectrometry MICE MOLECULAR structure NITRIC oxide NUCLEAR magnetic resonance spectroscopy PHARMACEUTICAL chemistry RESEARCH funding STATISTICS PLANT extracts DATA analysis DATA analysis software LIPOPOLYSACCHARIDES DESCRIPTIVE statistics |
| Zdroj: | Planta Medica; Sep2013, Vol. 79 Issue 14, p1335-1340, 6p |
| Abstrakt: | Three new neolignans, named 9-methoxyobovatol (6), magnobovatol (7), and 2-hydroxyobovaaldehyde (9), along with six known ones, magnolol (1), honokiol (2), isomagnolol (3), obovatol (4), obovatal (5), and obovaaldehyde (8), were isolated from the fruits of Magnolia obovata using silica gel and ODS column chromatography. From the results of spectroscopic data including EIMS, IR, ¹H- and 13C-NMR, DEPT, and 2D-NMR (gCOSY, gHSQC, gHMBC), the chemical structures were determined. All isolated compounds were evaluated for inhibition activity on nitric oxide production in LPS-induced RAW 264.7 cells, and compounds 1-4, 6, 7, and 9 showed significant activity with IC |
| Databáze: | Complementary Index |
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