| Autor: |
Atrasheuskaya, Alena, Petzelbauer, Peter, Fredeking, Terry M., Ignatyev, George |
| Předmět: |
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| Zdroj: |
FEMS Immunology & Medical Microbiology; Jan2003, Vol. 35 Issue 1, p33, 10p |
| Abstrakt: |
Here we describe a lethal mouse model infected with dengue virus type 2 with several similarities to human DEN-2 infection. Clinically animals demonstrated anemia, thrombocytopenia, pre-terminal paralysis and shock. The most impressive changes were seen with tumor necrosis factor (TNF)-α, which abruptly and steeply increased 24 h before the exitus (mean at day 6). Serum levels of IL-1β, IL-6, IL-10, IL-1 receptor antagonist and soluble TNF receptor I continuously increased during the time of infection. A 100% mortality rate was noted in that group of animals. Treating animals with anti-TNF-α serum reduced mortality rate down to 40% (P<0.05). Our model supports the view that activation of innate immune response is at least partially responsible for mortality in DEN-2 infection, and in line with this concept, anti-TNF treatment significantly reduces mortality rates. [Copyright &y& Elsevier] |
| Databáze: |
Complementary Index |
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