| Autor: |
Sawada, Kazuyoshi, Naiki, Mitsuru, Yago, Hisashi, Matsushita, Kohji, Ohtsuki, Toshiho, Kitagawa, Kazuo, Matsumoto, Masayasu, Hori, Masatsugu |
| Předmět: |
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| Zdroj: |
Clinical & Experimental Hypertension; Feb2003, Vol. 25 Issue 2, p73-84, 12p, 1 Chart |
| Abstrakt: |
The plasma thrombomodulin (TM) level, an indicator of systemic endothelial cell damage, was measured in spontaneously hypertensive rats (SHR), deoxycorticosteron acetate (DOCA)-induced hypertensive rats and normotensive Wistar-Kyoto (WKY) rats to clarify its changes in hypertension. Plasma TM levels, measured by enzymelinked immuno-sorbent assay, decreased with aging (5-20-weeks-old) in both SHR and WKY, and they were lower in SHR than age-matched WKY in all ages examined. Deoxycorticosteron acetate-induced hypertensive WKY also showed decreased TM levels compared with normotensive WKY. Accelerated coagulation and fibrinolysis shown by the increases in thrombin-antithrombin complex (TAT) and D-dimer levels were observed in both groups of hypertensive rats. These results suggest that hypertension may decrease plasma TM levels and induce a hypercoagulable state in rats. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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