| Autor: |
de Mello, Claudia Berlim, Rossi, Adriana Suzart Ungaretti, Cardoso, Thiago Da Silva Gusmão, Rivero, Thiago Strahler, De Moura, Luciana Monteiro, Nogueira, Roberto Gomes, Jackowski, Andréa Parolin, Bueno, Orlando Francisco Amoedo, Muszkat, Mauro |
| Předmět: |
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| Zdroj: |
Clinical Neuropsychiatry; Apr2013, Vol. 10 Issue 2, p45-54, 10p |
| Abstrakt: |
Objective: the investigation of distinctive neuropsychological characteristics in patients with the inattentive subtype of Attention Deficit Hyperactivity Disorder (ADHD) and their association with volumetric measures may improve our understanding of this disorder and contribute to discussions about the definition of the subtypes of ADHD. Method: in this study, a sample of 12 children diagnosed with ADHD-inattentive subtype and 11 typically developing children with ages ranging from 6 to 14 years were submitted to neuropsychological assessment and Magnetic Resonance Imaging, including morphological and morphometrical investigations (region of interest and voxel-based morphometry). For the ADHD-i group, the volumetric measures obtained using the region of interest (ROI) approach were also correlated with their neuropsychological performance. Results: the results did not reveal differences between the ADHD-i group and the control group with respect to the morphologic data, but the morphometric analysis indicated a reduction of the volume of the left medial frontal gyri, the left anterior cingulate, the left caudate, the left thalamus and the right postcentral gyrus grey matter in the ADHD-i group. The ADHD-i group performed worse on neuropsychological tasks related to selective and sustained attention, semantic and phonological verbal fluency, working memory and the time of execution on the selective attention tasks. Significant correlations were found between the volumetric measurements and the neuropsychological data. Conclusions: our results suggest that structural volume differences between the ADHD-i group and the control group can be identified using a more reined method of analysis, such as VBM, and that the ADHD-i group presents worse performance with respect to attention, working memory and phonological fluency compared to controls. Thus, our findings contribute to our understanding of the volumetric abnormalities and the neuropsychological indicators of ADHD-i, strengthening the clinical characterization of the inattentive subtype. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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