Synthesis, crystal structures, in vitro anticancer, and in vivo acute oral toxicity studies of bis-imidazolium/benzimidazolium salts and respective dinuclear Ag(I)- N -heterocyclic carbene complexes.

Autor:	Haque, Rosenani A., Hasanudin, Noorhafizah, Iqbal, Muhammad Adnan, Ahmad, Ashfaq, Hashim, Suzana, Abdul Majid, Ams, Ahamed, Mohamed B. Khadeer
Předmět:	COMPLEX compounds synthesis CRYSTAL structure ANTINEOPLASTIC agents ACUTE toxicity testing IMIDAZOLES SALTS SILVER compounds CARBENES FOURIER transform infrared spectroscopy
Zdroj:	Journal of Coordination Chemistry; Sep2013, Vol. 66 Issue 18, p3211-3228, 18p
Abstrakt:	The synthesis, spectral (FT-IR and NMR), and structural studies of 1,1?-methylene linked 3,3?-2-cyanobenzyl bis-imidazolium salt (L1) and respective dinuclear Ag(I)-NHC complex (C1) are reported. The structures of both compounds were established through single-crystal X-ray diffraction.C1has a short Ag–Ag separation of 3.16?Å. BothL1andC1were tested for potential against leukemia (k562) cell line. For comparison,para-xylyl linked bis-benzimidazolium salts (L2–L4) and their dinuclear Ag(I)-NHC complexes (C2–C4) were synthesized and tested against the same cell line (K562). The IC50values proved thatL2–L4andC2–C4are many fold more active thanL1andC1. The mechanism of action and structure activity relationship are discussed.In vivooral acute toxicity study (sighting study) was carried out which depicts that 2000 mg/kg dose of selected compounds is an appropriate and safe dose for conducting main study on animals. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
Externí odkaz:	Zobrazit plný text záznamu Plný text ve formátu HTML
Nepřihlášeným uživatelům se plný text nezobrazuje	K zobrazení výsledku je třeba se přihlásit.