| Autor: |
Gisclon, Lee G., Curtin, Christopher R., Fowler, Cynthia L., Williams, R. Rex, Hafkin, Barry, Natarajan, Jaya |
| Zdroj: |
Journal of Clinical Pharmacology; Aug1997, Vol. 37 Issue 8, p744-750, 7p |
| Abstrakt: |
A randomized, placebo-controlled, two-way crossover study in 16 healthy men was performed to determine the effect of orally administered levofloxacin at steady-state conditions, given at 500 mg every 12 hours, on the pharmacokinetics of theophylline given as a single 4.5-mg/kg intravenous infusion. Participants were assigned randomly to receive theophylline with levofloxacin in one study period and theophylline with placebo in the other period. Fourteen individuals completed the study. Mean (± SD) values for theophylline pharmacokinetic parameters for the levofloxacin and placebo treatments, respectively, were peak plasma concentrations (Cmax) of 11.4 (1.8) μg/mL and 10.7 (1.3) μg/mL; areas under the concentration time curve from time 0 extrapolated to infinity (AUC0-∞) of 124 (32) μg · hr/mL and 126 (30) μg · hr/mL; volumes of distribution at steady state (Vdss) 31.7 (3.5) L and 32.0 (3.9) L; clearances (Cl) of 48.6 (11.6) mL/min and 47.4 (10.3) mL/min; and half-lives (t1/2) of 8.1 (1.9) hours and 8.2 (1.8) hours. There were no statistically significant differences between treatments for any of these parameters. There was no pharmacokinetic interaction between levofloxacin administered orally at steady-state conditions and intravenously administered theophylline. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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