| Autor: |
Melia, Angela T., Zhi, Jianguo, Koss-Twardy, Susan G., Min, Bo H., Smith, Bettye L., Freundlich, Nancy L., Arora, Sujata, Passe, Sharon M. |
| Zdroj: |
Journal of Clinical Pharmacology; Aug1995, Vol. 35 Issue 8, p840-843, 4p |
| Abstrakt: |
To assess the influence of an orlistat-induced reduction in dietary fat absorption on the pharmacokinetics of digoxin, an open-label, placebo-controlled, randomized, two-way crossover study was performed in 12 healthy volunteers. Each subject received single 0.4-mg doses of digoxin (soft gelatin capsules) administered orally on the fourth day of orlistat (120 mg three times daily for 6 days) and placebo (three times daily for 6 days) treatment, separated by at least an 11-day washout period. Serial blood samples were collected before and at appropriate intervals after each digoxin dose to determine plasma concentrations of unchanged digoxin. The 90% confidence intervals for the ratio of geometric least-squares means (for Cmax, AUC0-48, AUC0-t, and AUC) and for the difference of arithmetic least-squares means (for tmax and Λz) indicate that the pharmacokinetics of digoxin was not altered by treatment with orlistat. This result suggests that a ∼30% reduction in dietary fat absorption will not change the efficacy of digoxin in cardiac patients. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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