| Autor: |
Baez, Mayra A., Woo-Ming, Rex B., Garg, Dyal C., Shapse, Deborah B., Deitch, Marc W., Weidler, Donald J. |
| Zdroj: |
Journal of Clinical Pharmacology; Apr1991, Vol. 31 Issue 4, p312-317, 6p |
| Abstrakt: |
This open crossover study in eight hypertensive patients defined a possible additive effect of oral guanabenz and captopril and determined a safe and effective dose range. Each group of four patients received placebo followed by ascending doses (on alternate days) of either guanabenz (2, 4, 8 mg) or captopril (6.25, 12.5, 25 mg) as initial monotherapy and were subsequently crossed over to the alternate monotherapy. Guanabenz and captopril were given concomitantly in increasing doses-the highest dose for both groups being 8 mg guanabenz/25 mg captopril. When guanabenz and captopril were given concomitantly, blood pressure decreased, both from the values during placebo administration and from the lead-in values recorded before each dose. Mean supine systolic and diastolic blood pressures after combination therapy decreased significantly ( P < .05) in a dose-related manner at most evaluations. The authors conclude that guanabenz and captopril have an additive effect when administered in combination to patients with hypertension. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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