| Autor: |
Danziger, Larry, Furmaga, Kevin M., Rodvold, Keith A., Bombeck, C. Thomas, Fischer, James H. |
| Zdroj: |
Journal of Clinical Pharmacology; Oct1989, Vol. 29 Issue 10, p946-952, 7p |
| Abstrakt: |
To study the pharmacokinetics and pharmacodynamics of two intravenous nizatidine dosing regimens, serial plasma concentrations and continuous intragastric pH were monitored simultaneously in 10 subjects with a documented history of duodenal or gastric ulcers. A 24-hour gastric pH profile was characterized for a 300 mg daily dose of nizatidine randomly administered both as 100 mg every 8 hours and 150 mg every 12 hours. No significant differences were observed in the mean pharmacokinetic parameters between the two dosing regimens. Pharmacodynamic parameters for the 100 mg every 8 hours versus the 150 mg every 12 hours regimen were not significantly different except for percent of time during the 24-hour study period that the pH was maintained >4 (43.6 ± 20.7 versus 34.7 ± 18.3, P < .05). A significant relationship was demonstrated for both regimens (P < .05) between the percent time pH > 4 and area under the plasma curve for the 24 hour study period. The lack of a significant difference in nizatidine pharmacokinetics between the two dosage regimens suggests a pharmacodynamic cause for the greater cumulative pH effect of the every 8 hour regimen. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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