| Autor: |
LASZLO, JOHN, LUCAS, VIRGIL S., HANSON, DEAN C., CRONIN, CAROL M., SALLAN, STEPHEN E. |
| Zdroj: |
Journal of Clinical Pharmacology; Aug1981 Supplement 1, Vol. 21 Issue S1, p51S-56S, 6p |
| Abstrakt: |
Thirty five patients were enrolled into a Phase I-II study of oral levonantradol being tested as an antiemetic for chemotherapy patients who were refractory to the aggressive use of standard antiemetic agents. Sixty-nine total courses were given. Dysphoric reactions (fear, anxiety, hallucinations) were the most serious side effects, and were most prevalent at the highest dose tested (2.0 mg q4h). Somnolence, a 'high' feeling, hypotension were also noted. Antiemetic responses were seen at 0.5, 1.0, 1.5 and 2.0 mg dose levels: the two intermediate doses gave responses comparable to those previously reported for oral THC. It is suggested that a combination of oral and parenteral levonantradol may prove to be a very effective program to relieve the otherwise disabling problems of persistent nausea and vomiting. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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