| Autor: |
Menaka K. B., Ramesh, Amitha, Thomas, Biju |
| Předmět: |
|
| Zdroj: |
Journal of Oral Health Research; Oct-Dec2011, Vol. 2 Issue 4, p111-117, 7p |
| Abstrakt: |
Aim: To assess and compare the levels of Nitric Oxide (NO) in Gingival Crevicular Fluid (GCF) and serum of chronic periodontitis (mild to moderate and severe) patients and healthy controls. Methods: The present comparative study comprised three groups, Group I: 30 healthy subjects without periodontitis as control group, Group II: 30 patients affected with mild to moderate periodontitis and Group III: 30 patients affected with advanced periodontitis. Thus, a total of 90 subjects in the age group 25-60 years participated. Patients with clinical attachment loss (CAL) of 2-4 mm and >5mm in at least 10 sites were classified as mild to moderate periodontitis and severe periodontitis respectively. NO levels in GCF and serum were assayed by measuring the accumulation of stable oxidative metabolite, nitrite with Griess reagent. Results: The mean value of NO levels in GCF among subjects with periodontal disease (Group 2 & Group 3) was significantly higher compared to control group i.e. (6.68 ± 0.75µM/l and 9.45± 0.94µM/l respectively compared to 3.75±0.73µM/l). Similarly the mean value of NO levels in serum among subjects with periodontal disease (Group 2 and Group3) was significantly higher compared to control group (Group1) i.e. (40.96 ± 6.58µM/l and 65.69 ± 6.00µM/l resp. compared to 22.98 ± 2.73µM/l). Conclusions: The findings from the study suggest that NO levels are increased in GCF and serum in subjects with periodontitis compared to healthy controls. The increase in NO levels was directly proportional to the severity of periodontal disease. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
|
