| Autor: |
Nagy, Ferenc, Nemes, Attila, Szűcsborus, Tamás, Ungi, Tamás, Katona, András, Sasi, Viktor, Zimmermann, Zsolt, Kalapos, Anita, Forster, Tamás, Ungi, Imre |
| Předmět: |
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| Zdroj: |
Central European Journal of Medicine; Oct2013, Vol. 8 Issue 5, p600-607, 8p |
| Abstrakt: |
Introduction: Invasive methods for assessment of coronary microcirculatory function are time- and instrumentation-consuming tools. Recently, novel computer-assisted videodensitometric methods have been demonstrated to provide quantitative information on myocardial (re)perfusion. The aim of the present prospective study was to evaluate the accuracy of videodensitometry-derived perfusion parameters in patients with stable angina undergoing elective coronary angiography. Methods: The study comprised 13 patients with borderline epicardial coronary artery stenosis (40-70%). Coronary flow reserve and index of microcirculatory resistance were measured by using an intracoronary pressure and temperature sensor-tipped guidewire. A videodensitometric quantitative parameter of myocardial perfusion was calculated by the ratio of maximal density (G) and the time to reach maximum density (T) of the time-density curves in regions of interest on conventional coronary angiograms. Myocardium perfusion reserve was calculated as a ratio of hyperemic and baseline G/T. Results: At hyperemia a significant increase in G/T could be observed (p <0.0001). Significant correlations were found between myocardium perfusion reserve and coronary flow reserve (r =0.82, p =0.0008) and between hyperemic G/T and hyperemic index of microcirculatory resistance (r =−0.72, p =0.0058). Conclusions: Videodensitometric Gmax/Tmax assessment seems to be a promising method to assess the myocardial microcirculatory state. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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