pH-Responsive Theranostic Polymer-Caged Nanobins: Enhanced Cytotoxicity and T1 MRI Contrast by Her2 Targeting.

Autor:	Hong, Bong Jin, Swindell, Elden P., MacRenaris, Keith W., Hankins, Patrick L., Chipre, Anthony J., Mastarone, Daniel J., Ahn, Richard W., Meade, Thomas J., O'Halloran, Thomas V., Nguyen, SonBinh T.
Předmět:	POLYMERIC nanocomposites THERAPEUTIC use of nanostructured materials HER2 protein THERAPEUTICS research POLYMERIC drug delivery systems DRUG stability
Zdroj:	Particle & Particle Systems Characterization; Sep2013, Vol. 30 Issue 9, p770-774, 5p
Abstrakt:	A polymer‐caged nanobin (PCN) theranostic platform with a doxorubicin (DXR)‐loaded liposomal core and an acid‐sensitive polymer shell that is functionalized with herceptin and GdIII‐based magnetic resonance imaging (MRI) contrast agents is reported. In vitro testing reveals an 120‐fold improvement in cellular GdIII uptake in comparison with clinically approved DOTA‐GdIII, leading to significant T1 MRI contrast enhancement. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
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