Diversity-Oriented Approach to Novel Spirocyclics via Enyne Metathesis, Diels-Alder Reaction, and a [2+2+2] Cycloaddition as Key Steps.

Autor: Kotha, Sambasivarao, Ali, Rashid, Tiwari, Arti
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Zdroj: Synlett; 2013, Vol. 24 Issue 15, p1921-1926, 6p
Abstrakt: A simple protocol for the synthesis of indane-based spirocyclics has been developed via enyne metathesis, Diels-Alder reaction, and a [2+2+2] cycloaddition as key steps starting from indane-1,3-dione. The key diene building block was assembled by enyne metathesis. In this sequence, rongalite is used as a green reagent to prepare the sultine intermediate, which is a useful precursor to generate the transient diene. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index