| Autor: |
Spada, Enea, Amoroso, Pietro, Taliani, Gloria, Zuccaro, Ornella, Chiriacò, Piergiorgio, Maio, Patrizia, Maio, Giuseppe, Esposito, Maria Luisa, Mariano, Corrado, Rinaldi, Roberto, Bellissima, Pietro, Tosti, Maria Elena, Del Porto, Paola, Francavilla, Ruggiero, Mellace, Vincenzo, Garbuglia, Anna Rosa, Folgori, Antonella, Mele, Alfonso |
| Předmět: |
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| Zdroj: |
Clinical Infectious Diseases; Sep2013, Vol. 57 Issue 6, p803-811, 9p |
| Abstrakt: |
IL28B.rs12979860 CC genotype has been associated with spontaneous clearance of hepatitis C virus (HCV). This prospective study suggests a relationship between CC genotype, HCV-specific T-cell response, and acute disease resolution, thus suggesting a possible important role of cell-mediated immunity in favoring HCV clearance in CC patients.Background. A single-nucleotide polymorphism (SNP; rs12979860) near the IL28B gene has been associated with spontaneous and treatment-induced hepatitis C virus clearance. We investigated predictors of spontaneous disease resolution in a cohort of patients with acute hepatitis C (AHC), analyzing epidemiological, clinical and virological parameters together with IL28B.rs12979860 genotypes and cell-mediated immunity (CMI).Methods. Fifty-six symptomatic AHC patients were enrolled and followed prospectively. CMI was measured in 31 patients at multiple time points by interferon-γ enzyme-linked immunospot assay and was correlated to the IL28B.rs12979860 SNP.Results. Eighteen patients had a self-limiting AHC that was associated with female sex (P = .028), older age (P = .018), alanine aminotransferase level >1000 U/L (P = .027), total bilirubin level >7 mg/dL (P = .036), and IL28B.rs12979860 genotype CC (P = .030). In multivariate analysis, only CC genotype was independently associated with self-limiting AHC (odds ratio, 5.3; 95% confidence interval, 1.1–26.5). Patients with the CC genotype with self-limiting AHC had a stronger (P = .02) and broader (P = .013) CMI than patients with the CT genotype with chronically evolving AHC. In patients with chronically evolving disease, CC genotype was associated with a broader CMI compared to CT genotype (P = .028). A negative CMI was more frequently associated with CT genotype among persistently infected patients (P = .043) and with persistent infection among CT patients (P = .033).Conclusions. Self-limiting AHC was independently associated with CC genotype. The correlation between IL28B.rs12979860 genotypes and CMI is suggestive of a possible important role of CMI in favoring hepatitis C virus clearance in CC patients. [ABSTRACT FROM PUBLISHER] |
| Databáze: |
Complementary Index |
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