| Autor: |
Vuillier, Françoise, Maloum, Karim, Thomas, Elaine K., Magnac, Christian, Dumas, Gérard, Payelle-Brogard, Béatrice, Oppezzo, Pablo, Dighiero, Guillaume, Scott-Algara, Daniel |
| Předmět: |
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| Zdroj: |
British Journal of Haematology; Jan2003, Vol. 120 Issue 2, p243-250, 8p |
| Abstrakt: |
Summary. Idiotypic structures of immunoglobulins from malignant B cells constitute tumour-specific antigens, though the function of immunoglobulin-specific CD8+ T cells in disease control and rejection remains unclear. We have studied five cases of B chronic lymphocytic leukaemia patients affected with indolent (three patients) or aggressive (two patients) disease. We showed that CD8+ T cells with major histocompatibility complex class I-restricted cytotoxicity against autologous tumour B cells could be generated following repeated stimulations with idiotype-pulsed dendritic cells in vitro . CD8+ T-cell lines were able to upregulate CD69 expression and to release interferon (IFN)-γ upon contact with the autologous B cells, though cytolytic activity was only substantiated for patients with indolent disease. The failure of cytolytic activity in patients with aggressive disease may be explained by a skewed maturation of memory CD8 cells. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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