| Autor: |
Iversen, Astrid K.N., Christiansen, Claus Bohn, Attermann, Jørn, Eugen-Olsen, Jesper, Schulman, Sam, Berntorp, Erik, Ingerslev, Jørgen, Fugger, Lars, Scheibel, Elma, Tengborn, Lilian, Gerstoft, Jan, Dickmeiss, Ebbe, Svejgaard, Arne, Skinhøj, Peter |
| Předmět: |
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| Zdroj: |
Journal of Infectious Diseases; 1/15/2003, Vol. 187 Issue 2, p215, 11p |
| Abstrakt: |
The relationship among CCR5 genotype, cytomegalovirus infection, and disease progression and death was studied among 159 human immunodeficiency virus (HIV)-infected patients with hemophilia. One patient (0.6%) had the CCR5Δ32/CCR5Δ32 genotype (which occurs in ∼2% of the Scandinavian population) and a rapid disease course. His HIV V3 region contained genotypic features attributable to X4 virus and resembled functionally verified X4 virus and virus from patients treated with a CD4 cell-stimulating drug, tucaresol. Age-related differences in disease progression rate and survival time were seen for CCR5/CCR5 patients. Surprisingly, no protective effect of the CCR5/CCR5A32 genotype on disease progression or survival was seen for children but was evident for adults. Age group-related immunologic differences might explain this variation, and transmission route and/or viral phenotype variation within donor virus may be related to the limited protection of the CCR5Δ32/CCR5&Δ32 genotype. Sequence comparisons indicate that X4 virus can be selected in vivo due to either absence of CCR5 receptors or relative increase of CXCR4 receptors. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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