| Autor: |
Koldin, I., Treshchalina, E., Sharovskaya, Yu., Dubovaya, T., Kobliakov, V. |
| Zdroj: |
Cell & Tissue Biology; Jul2013, Vol. 7 Issue 4, p329-334, 6p |
| Abstrakt: |
To study the role of the cellular microenvironment in tumor promotion and progression, transformed cells of rat embryonic fibroblasts (CL-1 clone) were transplanted into transgenic immunodeficient mice and cells of the formed tumor were converted into culture (CL-1-1 cells). Cells before and after transplantation were compared in morphology, growth rate, and permeability of intercellular gap junction. CL-1-1 cells were shown to have a changed morphology, to grow faster than the CL-1 cell, and to have no contact inhibition. In the G phase of the cell cycle, there were many more CL-1 than CL-1-1 cells, whereas, in the G and M phases, CL-1-1 cells were predominant. The permeabilities of the gap junction in the CL-1 and CL-1-1 cells were approximately the same. It was concluded that the cell microenvironment can stimulate tumor promotion and tumor progression upon transplantation of transformed cells into immunodeficient animals. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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