| Autor: |
Suzuki, Takeyuki, Ishizaka, Yuka, Ghozati, Kazem, Zhou, Da-Yang, Asano, Kaori, Sasai, Hiroaki |
| Předmět: |
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| Zdroj: |
Synthesis; 2013, Vol. 45 Issue 15, p2134-2136, 3p |
| Abstrakt: |
Asymmetric tandem coupling of meso-diols with aldehydes was achieved by using a chiral iridium catalyst. This tandem reaction consists of oxidative desymmetrization of the meso-diol, aldol condensation with an aldehyde, and reduction of the enone intermediate. A one-pot method using an excess of a hydrogen donor gave a-benzyl-ß-hydroxyindan-1-ones in up to 94% ee and 88% yield. An asymmetric hydrogen autotransfer method in the absence of an additional hydrogen donor gave the desired benzyl ketone in 92% ee. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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