| Autor: |
Angelidi, A., Protopsaltis, I., Dimitriadou, A., Kornezos, I., Gritzapis, A., Sergentanis, T., Verras, C., Kranidiotis, G., Melidonis, A. |
| Předmět: |
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| Zdroj: |
Scientific Chronicles / Epistimonika Chronika; Jan2013, p23-28, 6p |
| Abstrakt: |
Background: Endothelial progenitor cells (EPCs) have recently been considered as a potential novel biomarker of vascular integrity, atherosclerosis and cardiovascular risk. Aim: This study was performed to investigate the main determinants of EPC levels in individuals with prediabetes. Materials - Methods: Thirty-nine subjects with newly diagnosed prediabetes were enrolled. Flow cytometry was used to quantify EPCs (CD34+VEGFR-2+). Traditional risk factors, high-sensitivity C-reactive protein (hs-CRP), homeostasis model assessment of insulin resistance (HOMA-IR) and anthropometric parameters, including ultrasonographic quantification of visceral and subcutaneous fat, were recorded. Results: At the univariate analysis, EPC levels significantly and negatively correlated with waist circumference (p=0.017), mean arterial pressure (p=0.009), total cholesterol (p=0.003), hs-CRP (p=0.006), HOMA-IR (p=0.031) and visceral fat (p=0.040). However, at the stepwise multivariate ordinal logistic regression analysis, only visceral fat retained its statistical significance (OR=0.79, 95%Cl:0.64-0.98,p=0.032). Conclusions: Visceral fat seems to be the main determinant of EPC levels in individuals with prediabetes and a plausible link between mild metabolic abnormalities, cardiovascular risk and vascular homeostasis process. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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