| Autor: |
PARK, SANDY, POLZIN, JENNIFER K., RHO, JAY P. |
| Předmět: |
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| Zdroj: |
California Journal of Health-System Pharmacy; May/Jun2013, Vol. 25 Issue 3, p90-94, 5p |
| Abstrakt: |
Purpose Bisphosphonate therapy is recommended for men and women with osteoporosis but there are few studies assessing bisphosphonate adherence specifically in men. Within Kaiser Permanente Southern California, a health-maintenance organization, a 250% increase in men receiving anti-osteoporosis medication annually was seen between 2002 to 2007. The purpose of this study was to assess compliance and persistence of alendronate in the elderly male osteoporosis population within Kaiser Permanente Southern California. Compliance and persistence rates were compared to that reported in women. Methods We conducted a retrospective database review of men with osteoporosis, age 70 years or older initiated on alendronate 70mg weekly tablets. Medication possession ratio (MPR) over one year, compliance rate, mean number of days to non-persistence and persistence on Day 365 were assessed (allowable refill gap was 30 days). The relationship between compliance, age and smoking were also assessed. Results We identified 2545 men initiated on alendronate weekly therapy from January 2008 to August 2009. Mean MPR was 0.675 + 0.32. The alendronate one-year compliance rate was 49.6% (n=1262). No difference was found between the number of smokers in the compliant and non-compliant groups. The compliant group was slightly younger than the non-compliant group (78.5 + 5.6 vs. 79 + 5.6 years, p<0.05). Persistence rate of alendronate therapy over the one-year period was 34.4% (n=875). Persistence rate on day 365 was 51.1%. The mean time to non-persistence was 138 + 91.4 days. Conclusions We conclude that compliance and persistence of alendronate therapy among males with osteoporosis is low similar to that reported in women. There appears to be no substantial relationship between gender and compliance. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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