Low-Density Lipoprotein Cholesterol: How Low Can We Go?

Autor:	Sherbet, Daniel, Garg, Puja, Brilakis, Emmanouil, Banerjee, Subhash
Předmět:	CARDIOVASCULAR disease prevention CORONARY heart disease prevention DRUG therapy for hyperlipidemia ANTILIPEMIC agents GENETIC disorders LOW density lipoproteins STATINS (Cardiovascular agents) DISEASE complications
Zdroj:	American Journal of Cardiovascular Drugs; Aug2013, Vol. 13 Issue 4, p225-232, 8p, 2 Charts
Abstrakt:	Elevated low-density lipoprotein cholesterol (LDL-C) is an established cause of cardiovascular disease and subsequent adverse events. The efficacy and safety of lowering plasma LDL-C to reduce the risk of coronary heart disease (CHD) and secondary event rates are now well established. What has not been established, however, is a plasma LDL-C lower threshold level of safety and efficacy. Here we review intensive plasma LDL-C-lowering with statins and argue that even further reductions of plasma LDL-C than current guideline targets is likely to safely reduce cardiovascular event rates. We discuss how to achieve very low levels of plasma LDL-C using both traditional and novel LDL-lowering therapies. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
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