| Autor: |
Manenti, Giacomo, Peissel, Bernard, Gariboldi, Manuela, Falvella, F Stefania, Zaffaroni, Daniela, Allaria, Biagino, Pazzaglia, Simonetta, Rebessi, Simonetta, Covelli, Vincenzo, Saran, Anna, Dragani, Tommaso A |
| Předmět: |
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| Zdroj: |
Oncogene; 11/9/2000, Vol. 19 Issue 47, p5324, 5p, 1 Black and White Photograph, 3 Charts, 1 Graph |
| Abstrakt: |
The parathyroid hormone-related protein (PTHrP) gene (Pthlh) maps in the distal region of mouse chromosome 6 that contains a quantitative trait locus associated with genetic predisposition to skin tumorigenesis. Here, we report a genetic polymorphism located in the osteostatin encoding region of the Pthlh gene and that produces Thr/Pro PTHrP variants. PthlhThr and PthlhPro alleles were significantly linked with resistance and susceptibility to skin carcinogenesis in phenotypically selected Car-R and Car-S outbred mice. Transfection of human NCI-H520 squamous cell carcinoma cells with the PthlhPro allele resulted in cells growing in clusters, tending to pile up, and growing at a significantly faster rate in nude mice than non-transfected and PthlhThr-transfected cells. These results point to the role of the Pthlh gene as a cancer modifier gene in skin tumorigenesis. Oncogene (2000) 19, 5324–5328. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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