| Autor: |
Vásquez-Garzón, Verónica Rocío, Macias-Pérez, José Roberto, Jiménez-García, Mónica Noemí, Villegas, Vanessa, Fattel-Fazenta, Samia, Villa-Treviño, Saúl |
| Předmět: |
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| Zdroj: |
Toxicologic Pathology; Aug2013, Vol. 41 Issue 6, p857-865, 9p |
| Abstrakt: |
In this study of chemoprevention in the rat modified resistant hepatocyte model, preneoplastic cells were diminished by >60% with quercetin pretreatment compared with those rats treated with N-Diethylnitrosamine (DEN) to induce liver cancer. This decrease occurred associated with an abolished DEN-induced lipid peroxidation as well as activation of caspase 9 and increased caspase 3, as determined by increased expression of cleaved caspase 3 and 9, but not cleaved caspase 8 and increased fragmentation of Poly (ADP-ribose) polymerase (PARP) inducing apoptosis of presumed genetically injured cells, when quercetin was administered before the initiation agent. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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