| Autor: |
Vanacore, N., Nappo, A., Gentile, M., Brustolin, A., Palange, S., Liberati, A., Di Rezze, S., Caldora, G., Gasparini, M., Benedetti, F., Bonifatti, V., Forastiere, F., Quercia, A., Meco, G. |
| Předmět: |
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| Zdroj: |
Neurological Sciences; Sep2002 Supplement 2, Vol. 23, pS119, 2p |
| Abstrakt: |
In the last two years, the environmental theory on the aetiology of Parkinson disease has acquired new data. From an experimental point of view, a new model of parkinsonism induced by rotenone, a diffuse insecticide, has been proposed, and in vitro studies have provided proof that several pesticides stimulate the formation of α-synuclein fibrils (one of the principal constituents of Lewy bodies). Moreover, a meta-analysis of all case-control studies so far performed showed a positive, statistically significant association between pesticide exposure and PD. In this context, we are performing a cohort study on 5575 licensed pesticide users in the province of Viterbo. After 27 years of follow-up, 4788 subjects are still alive. The aim of this study is to measure the prevalence of Parkinson's disease in a large group of workers with theoretically increased risk. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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