| Autor: |
Iwasaki, Shin-ichi, Sudo, Tamotsu, Miwa, Maiko, Ukita, Masayo, Morimoto, Akemi, Tamada, Masaru, Ueno, Sayaka, Wakahashi, Senn, Yamaguchi, Satoshi, Fujiwara, Kiyoshi, Sakuma, Yoshiko, Mikami, Yoshiki, Nishimura, Ryuichiro |
| Předmět: |
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| Zdroj: |
Archives of Gynecology & Obstetrics; Aug2013, Vol. 288 Issue 2, p385-391, 7p, 1 Color Photograph, 3 Charts, 2 Graphs |
| Abstrakt: |
Purpose: Endometrial stromal sarcomas (ESSs) are rare tumors and are divided into two groups: low-grade endometrial stromal sarcoma (ESS-LG) and undifferentiated endometrial sarcoma (UES). The purpose of this study was to compare the clinicopathological features and immunophenotypes of ESS-LG and UES. Methods: The authors evaluated 16 patients diagnosed with ESS at the Hyogo Cancer Center, reviewed their files and data, and performed an immunohistochemical study for oncogenic proteins (EGFR, PDGFR-α, and PDGFR-β) and cell cycle regulators (cyclin D1, cyclin E, p16, p21, p27, and p53) to compare ESS-LG and UES using the World Health Organization (WHO) classification. Results: Four cases (25 %) were classified as ESS-LGs and 12 (75 %) as UES. Patients with UES had a significantly worse overall survival than did those with ESS-LG ( p = 0.0445). Although no ESS-LGs showed expression of p16, 10 of 12 (83 %) UESs showed expression of p16. UESs showed a trend toward higher expression of cyclin D1, p21, and p53 compared with ESS-LGs. Conclusions: Our data emphasize the clinical importance of the WHO classification of ESS. It is of utmost importance to establish a proper classification to increase the consistency of data that may be useful for improving clinical and therapeutic management of patients with ESS. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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