| Abstrakt: |
cell necrosis and high mortality rate have been reported in poisoning by fungi Amanita Phalloides. In this study, antioxidant and sitoprotective effects of Erythropoietin (EPO) and L-Carnitin was investigated preventing effects on induced liver injury. In each groups,with weights between 40-50 gr musculus type 10 male mice were used and formed 6 groups. Respectively group with control group (Group 1), only α-Amanitin applied (Group 2), α-Amanitin+ EPO applied (Group 3), α-Amanitin+L-Carnitin applied(Group 4), only EPO applied (Group 5), only L-carnitin applied (group 6). Liver tissue MDA, GPx and Catalase, serum ALT and AST were studied. Compared to a combination of all groups, serum AST levels and tissue MDA and CAT levels found statistically significant difference (p values < 0,001; 0,003 and 0,005). Among the groups in serum ALT, tissue MDA, tissue CAT and GPx levels, there was no significant difference (for all p values > 0,05). Serum AST levels were significantly higher in Group 2 than Group 1 (p=0,014), higher in Group 3 than Group 2 (p= 0,01), lower Group 6 than Group 1(p=0,016). The results of biochemical studies evaluated that experimental animals in group 2 applied Amanita Phalloides did not cause toxic effect enough, serum AST levels also influenced by other factors such as hemolysis except for liver damage. Therfore serum AST levels may have been different among the groups. Histopathologic examination of tissue may be more descriptive information. [ABSTRACT FROM AUTHOR] |
